Cardio-Respiratory

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The cardiovascular and the respiratory systems are essential to maintain the body homeostasis. The basic homeostatic regulations are orchestrated by tonic mechanism that control blood pressure and breathing. These functions are compromised in a large number of pathological states such as myocardial infarction, congestive heart failure, stroke, hypertension, hypoxia, respiratory syndromes, and sleep disorders.

Changes in the cardio-respiratory reflex adjustments, cardiac hemodynamic and vascular reactivity of distinct territories are inherent factors linked to the development of those pathologies. Therefore, the physiology cardio-respiratory group is committed to unraveling the physiological process involved in the peripheral (vascular smooth muscle and heart hemodynamic) and central (cardio-repiratory reflex) control of the arterial pressure and breathing.

To reach these goals, we have a variety of experimental approaches including hemodynamic recordings (arterial pressure, heart rate, skeletal muscle blood flow and peripheral resistance), vascular reactivity in isolated vessels and in perfused vascular beds, electrophysiology recordings in vivo and in vitro (unit recording, sympathetic and respiratory activities), gene therapy with viral vectors transfer in vivo into the distinct central autonomic nuclei, image analysis techniques, immunohistochemistry, in situ hybridization, RT-PCR, biochemical and molecular assays, computational simulation and exercise training. The group is composed by four team’s leaders: Lisete Compagno Michelini, Luciana Venturini Rossoni, Vagner Roberto Antunes, and Thiago dos Santos Moreira.